Laboratory of Pharmaceutical, Design & Synthesis, Northwest A&F University, Yangling 712100, PR China.
Mini Rev Med Chem. 2011 Sep;11(10):901-9. doi: 10.2174/138955711796575461.
Podophyllotoxin, one of the well-known naturally occurring aryltetralin lignans, has been used as the lead-compound for the preparation of potent anticancer agents, such as etoposide, teniposide, and etopophos. In our previous review, we described the advances of podophyllotoxin derivatives from 2003 and 2007. In recent years, an increased number of interesting research work has been carried out on the podophyllotoxins. As a continuation, the present review summarizes and highlights the update advances of podophyllotoxin derivatives from 2008 and 2010 in regard to semisynthesis, biosynthesis, biological activities, mode of action and structure-biological activity relationship.
鬼臼毒素是一种著名的天然芳基四氢萘木脂素，曾被用作制备有效抗癌药物的先导化合物，如依托泊苷、替尼泊苷和依托泊苷磷酸。在我们之前的综述中，我们描述了 2003 年至 2007 年鬼臼毒素衍生物的进展。近年来，人们对鬼臼毒素进行了越来越多的有趣研究。作为延续，本综述总结并强调了 2008 年至 2010 年鬼臼毒素衍生物在半合成、生物合成、生物活性、作用模式和构效关系方面的最新进展。
