Singh K, Arora D, Singh K, Singh S
Organic Synthesis Laboratory, Department of Applied Chemical Sciences & Technology, Guru Nanak Dev University, Amritsar - 143 005, India.
Mini Rev Med Chem. 2009 Jan;9(1):95-106. doi: 10.2174/138955709787001686.
In the armamentarium of calcium channel blockers appropriately functionalized 3,4-dihydropyrimidin-2(1H)-ones have received considerable attention in recent past owing to their structural similarity with 1,4-dihydropyridine based drugs. In this review, we highlight detailed investigations in the calcium channel blocking and other activities of this category of compounds as well as trace their genesis from 1,4-dihydropyridine based drugs.
在钙通道阻滞剂的药物库中，适当功能化的3,4-二氢嘧啶-2(1H)-酮类化合物由于其与基于1,4-二氢吡啶的药物结构相似，在最近受到了相当大的关注。在这篇综述中，我们重点介绍了对这类化合物的钙通道阻滞及其他活性的详细研究，以及追溯它们从基于1,4-二氢吡啶的药物衍生而来的过程。
