用于皮肤再生的等离子体处理丝素蛋白纳米纤维
Plasma-treated silk fibroin nanofibers for skin regeneration.
作者信息
Jeong Lim, Yeo In-Sung, Kim Ha Na, Yoon Young Il, Jang Da Hyun, Jung Sung Youn, Min Byung-Moo, Park Won Ho
机构信息
Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon, Republic of Korea.
出版信息
Int J Biol Macromol. 2009 Apr 1;44(3):222-8. doi: 10.1016/j.ijbiomac.2008.12.008. Epub 2008 Dec 25.
Silk fibroin (SF) nanofibers were prepared by electrospinning and treated with plasma in the presence of oxygen or methane gas to modify their surface characteristics. The surface characteristics of the SF nanofibers after plasma treatment were examined using contact angle measurements and XPS analysis. The hydrophilicity of the electrospun SF nanofibers decreased slightly by the CH(4) plasma treatment. On the other hand, the hydrophilicity of the SF nanofibers increased greatly by an O(2) plasma treatment. The O(2)-treated SF nanofibers showed higher cellular activities for both normal human epidermal keratinocytes (NHEK) and fibroblasts (NHEF) than the untreated ones.
通过静电纺丝制备丝素蛋白（SF）纳米纤维，并在氧气或甲烷气体存在的情况下用等离子体处理以改变其表面特性。使用接触角测量和XPS分析来检测等离子体处理后SF纳米纤维的表面特性。经CH(4)等离子体处理后，静电纺丝SF纳米纤维的亲水性略有下降。另一方面，经O(2)等离子体处理后，SF纳米纤维的亲水性大幅增加。与未处理的SF纳米纤维相比，经O(2)处理的SF纳米纤维对正常人表皮角质形成细胞（NHEK）和成纤维细胞（NHEF）均表现出更高的细胞活性。
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