瞬时受体电位锚蛋白1：一种镇咳治疗的潜在靶点。
TRPA1: a potential target for anti-tussive therapy.
作者信息
Taylor-Clark Thomas E, Nassenstein Christina, McAlexander M Allen, Undem Bradley J
机构信息
Division of Allergy and Clinical Immunology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA.
出版信息
Pulm Pharmacol Ther. 2009 Apr;22(2):71-4. doi: 10.1016/j.pupt.2008.12.019. Epub 2008 Dec 31.
Cough occurs as a result of the activation of specific airway sensory nerves. The mechanisms by which tussive stimuli activate these sensory nerves are starting to be understood and suggest that TRPA1 channels are heavily involved. TRPA1 channels are nociceptor-specific ion channels that are gated by a wide range of exogenous irritants and endogenously-produced inflammatory mediators, suggesting that the blockade of TRPA1 represents a novel therapy for the treatment of cough in humans.
咳嗽是特定气道感觉神经激活的结果。咳嗽刺激激活这些感觉神经的机制正开始被了解，这表明瞬时受体电位锚蛋白1（TRPA1）通道密切相关。TRPA1通道是伤害感受器特异性离子通道，可被多种外源性刺激物和内源性产生的炎症介质激活，这表明阻断TRPA1代表了一种治疗人类咳嗽的新疗法。
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