药物发现中的分子场：是走向衰老还是走向成熟？
Molecular fields in drug discovery: getting old or reaching maturity?
机构信息
Molecular Discovery Limited, 215 Marsh Road, Pinner, Middlesex, London HA5 5NE, United Kingdom.
出版信息
Drug Discov Today. 2010 Jan;15(1-2):23-32. doi: 10.1016/j.drudis.2008.12.006. Epub 2009 Jan 14.
PMID:19150413
Abstract
With GRID first published 23 years ago, and CoMFA 20 years ago, the two most widely known methods that apply molecular fields to drug discovery are now into their third decade. Are molecular-field-based methods still applicable to modern drug discovery? Are they old and outdated? Or are they maturing into their full potential?
摘要
GRID 首次发表于 23 年前，CoMFA 则是 20 年前，这两种应用分子场于药物发现的最广为人知的方法现已进入第三个十年。基于分子场的方法是否仍然适用于现代药物发现？它们是否已经过时？还是正在成熟并发挥其全部潜力？
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