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局部青光眼性视野缺损与通过偏振仪和光谱域光学相干断层扫描测量的神经纤维层厚度损失之间的相关性。

Correlation between local glaucomatous visual field defects and loss of nerve fiber layer thickness measured with polarimetry and spectral domain OCT.

作者信息

Horn Folkert K, Mardin Christian Y, Laemmer Robert, Baleanu Delia, Juenemann Anselm M, Kruse Friedrich E, Tornow Ralf P

机构信息

Universitätsklinikum, Augenklinik, Erlangen, Germany.

出版信息

Invest Ophthalmol Vis Sci. 2009 May;50(5):1971-7. doi: 10.1167/iovs.08-2405. Epub 2009 Jan 17.

Abstract

PURPOSE

To study the correlation between local perimetric field defects and glaucoma-induced thickness reduction of the nerve layer measured in the peripapillary area with scanning laser polarimetry (SLP) and spectral domain optical coherence tomography (SOCT) and to compare the results with those of a theoretical model.

METHODS

The thickness of the retinal nerve fiber layer was determined in 32 sectors (11.25 degrees each) by using SLP with variable cornea compensation (GDxVCC; Laser Diagnostics, San Diego, CA) and the newly introduced high-resolution SOCT (Spectralis; Heidelberg Engineering, Heidelberg, Germany). Eighty-eight healthy subjects served as control subjects, to determine the thickness deviation in patients with glaucoma. The relationship between glaucomatous nerve fiber reduction and visual field losses was calculated in six nerve fiber bundle-related areas. Sixty-four patients at different stages of open-angle glaucoma and 26 patients with ocular hypertension underwent perimetry (Octopus G1; Haag-Streit, Köniz, Switzerland) and measurements with the two morphometric techniques.

RESULTS

Sector-shaped analyses between local perimetric losses and reduction of the retinal nerve fiber layer thickness showed a significant association for corresponding areas except for the central visual field in SLP. Correlation coefficients were highest in the area of the nasal inferior visual field (SOCT, -0.81; SLP, -0.57). A linear model describes the association between structural and functional damage.

CONCLUSIONS

Localized perimetric defects can be explained by reduced nerve fiber layer thickness. The data indicate that the present SOCT is useful for determining the functional-structural relationship in peripapillary areas and that association between perimetric defects and corresponding nerve fiber losses is stronger for SOCT than for the present SLP. (ClinicalTrials.gov number, NCT00494923.).

摘要

目的

研究局部视野缺损与青光眼导致的视乳头周围区域神经层厚度降低之间的相关性,该神经层厚度通过扫描激光偏振仪(SLP)和光谱域光学相干断层扫描(SOCT)测量,并将结果与理论模型的结果进行比较。

方法

使用具有可变角膜补偿功能的SLP(GDxVCC;激光诊断公司,加利福尼亚州圣地亚哥)和新推出的高分辨率SOCT(Spectralis;海德堡工程公司,德国海德堡),在32个扇区(每个扇区11.25度)中测定视网膜神经纤维层的厚度。88名健康受试者作为对照,以确定青光眼患者的厚度偏差。在六个与神经纤维束相关的区域计算青光眼性神经纤维减少与视野缺损之间的关系。64例不同阶段开角型青光眼患者和26例高眼压症患者接受了视野检查(Octopus G1; Haag-Streit公司,瑞士科尼兹)以及这两种形态测量技术的测量。

结果

局部视野缺损与视网膜神经纤维层厚度降低之间的扇形分析显示,除SLP测量的中心视野外,相应区域之间存在显著相关性。鼻下视野区域的相关系数最高(SOCT为 -0.81;SLP为 -0.57)。线性模型描述了结构和功能损害之间的关联。

结论

局部视野缺损可通过神经纤维层厚度降低来解释。数据表明,目前的SOCT有助于确定视乳头周围区域的功能 - 结构关系,并且与目前的SLP相比,SOCT测量的视野缺损与相应神经纤维损失之间的关联更强。(ClinicalTrials.gov编号,NCT00494923。)

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