Yalvac Ilgaz Sagdic, Altunsoy Muhsin, Cansever Semra, Satana Banu, Eksioglu Umit, Duman Sunay
Glaucoma Department, Yeditepe University Eye Hospital, Istanbul, Turkey.
J Glaucoma. 2009 Jan;18(1):53-61. doi: 10.1097/IJG.0b013e318179f751.
To study the correlation between known visual field defects and retinal nerve fiber layer (RNFL) thickness detected by optical coherence tomography (OCT) in glaucomatous eyes.
Visual field parameters and OCT RNFL measurements of 28 eyes of 28 glaucoma patients with various stages of glaucoma were compared with 38 eyes of 38 normal age-matched controls. A perimetric nerve fiber bundle map was built by dividing the visual field area into 21 zones. Mean deviation and pattern standard deviation values within these 21 zones were compared with OCT RNFL thickness measurements in 12 sectors and the results were analyzed.
Average RNFL thickness was 62.90+/-16.56 microm in the glaucoma group and 111.90+/-6.00 microm in the control group (P<0.05). Pattern standard deviation and mean deviation visual field zones and corresponding OCT RNFL thickness sectors were significantly correlated at specific sectors in the glaucoma group (P<0.01).
Analysis of RNFL thickness in eyes with focal glaucomatous visual field defects showed good structural and functional correlation with OCT. OCT contributes to the identification of focal defects in the RNFL of glaucoma patients.
研究青光眼患者已知视野缺损与光学相干断层扫描（OCT）检测的视网膜神经纤维层（RNFL）厚度之间的相关性。
将28例不同青光眼阶段的青光眼患者的28只眼的视野参数和OCT RNFL测量结果与38例年龄匹配的正常对照者的38只眼进行比较。通过将视野区域划分为21个区域构建周边神经纤维束图。将这21个区域内的平均偏差和模式标准偏差值与12个扇区的OCT RNFL厚度测量值进行比较，并对结果进行分析。
青光眼组平均RNFL厚度为62.90±16.56微米，对照组为111.90±6.00微米（P<0.05）。青光眼组特定扇区的模式标准偏差和平均偏差视野区域与相应的OCT RNFL厚度扇区显著相关（P<0.01）。
对有局灶性青光眼视野缺损的眼睛进行RNFL厚度分析显示，与OCT具有良好的结构和功能相关性。OCT有助于识别青光眼患者RNFL中的局灶性缺损。
