Rac1小GTP酶：身兼数职的“Rac”
Rac1 GTPase: a "Rac" of all trades.
作者信息
Bosco E E, Mulloy J C, Zheng Y
机构信息
Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
出版信息
Cell Mol Life Sci. 2009 Feb;66(3):370-4. doi: 10.1007/s00018-008-8552-x.
Abstract
Rac1, a member of the Rho family of GTPases, is an intracellular transducer known to regulate multiple signaling pathways that control cytoskeleton organization, transcription, and cell proliferation. Deregulated expression or activation patterns of Rac1 can result in aberrant cell signaling and numerous pathological conditions. Here, we highlight the physiological functions and signaling mechanisms of Rac1 and their relevance to disease.
摘要
Rac1是小GTP酶Rho家族的成员之一，是一种细胞内转导分子，已知其可调节多种控制细胞骨架组织、转录和细胞增殖的信号通路。Rac1表达失调或激活模式异常可导致异常的细胞信号传导和多种病理状况。在此，我们重点介绍Rac1的生理功能和信号传导机制及其与疾病的相关性。
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