Pottgiesser T, Specker W, Umhau M, Roecker K, Schumacher Y O
Medizinische Universitätsklinik, Abteilung Rehabilitative und Präventive Sportmedizin, Freiburg, Germany.
Vox Sang. 2009 Feb;96(2):119-27. doi: 10.1111/j.1423-0410.2008.01129.x.
Total haemoglobin mass (tHb) as a direct parameter of the blood system and ultimate target of all blood transfusions has not been evaluated for its post-transfusion survival and stability. Therefore, the purpose of this study was to investigate the latter which may also be relevant from an anti-doping perspective as autologous blood transfusions remain impossible to detect.
The tHb was determined by the CO rebreathing method prior to and after donation of 1 unit of whole blood, as well as prior to and after reinfusion (weekly up to 56 days) of the erythrocyte concentrate in 10 men (28 +/- 7 years, 181 +/- 7 cm, 76 +/- 12 kg).
The mean tHb content of the derived erythrocyte concentrate was 60 +/- 3 g, while the net tHb increases after transfusion of 51 g (95% confidence intervals 33-69 g) permitted proof of an elevated tHb for at least 56 days after transfusion.
The results show that an elevated tHb induced by autologous transfusion allowed continuous identification although, as expected, a slow decrease of tHb has been revealed in the observation period. In reference to anti-doping, CO rebreathing permits proof of a supraphysiologically elevated tHb but possibly only if a stable baseline value is known.
作为血液系统的直接参数以及所有输血的最终目标，全血红蛋白质量（tHb）的输血后存活及稳定性尚未得到评估。因此，本研究的目的是调查后者，从反兴奋剂角度来看这可能也具有相关性，因为自体输血仍然无法被检测到。
通过一氧化碳重呼吸法在10名男性（年龄28±7岁，身高181±7厘米，体重76±12千克）捐献1单位全血之前和之后，以及输注红细胞浓缩液之前和之后（每周一次，直至56天）测定tHb。
所获得的红细胞浓缩液的平均tHb含量为60±3克，而输血后tHb净增加51克（95%置信区间33 - 69克），这证明输血后至少56天tHb升高。
结果表明，尽管在观察期内如预期的那样tHb缓慢下降，但自体输血诱导的tHb升高仍可持续识别。关于反兴奋剂，一氧化碳重呼吸法能够证明tHb超生理升高，但可能只有在已知稳定基线值的情况下才行。
