抑制控制受损与自闭症谱系障碍中的高阶重复行为有关。
Impaired inhibitory control is associated with higher-order repetitive behaviors in autism spectrum disorders.
作者信息
Mosconi M W, Kay M, D'Cruz A-M, Seidenfeld A, Guter S, Stanford L D, Sweeney J A
机构信息
Department of Psychiatry, Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
出版信息
Psychol Med. 2009 Sep;39(9):1559-66. doi: 10.1017/S0033291708004984. Epub 2009 Jan 21.
Abstract
BACKGROUND
Impairments in executive cognitive control, including a reduced ability to inhibit prepotent responses, have been reported in autism spectrum disorders (ASD). These deficits may underlie patterns of repetitive behaviors associated with the disorder.
METHOD
Eighteen individuals with ASD and 15 age- and IQ-matched healthy individuals performed an antisaccade task and a visually guided saccade control task, each with gap and overlap conditions. Measures of repetitive behaviors were obtained using the Autism Diagnostic Inventory-Revised (ADI-R) and examined in relation to neurocognitive task performance.
RESULTS
Individuals with an ASD showed increased rates of prosaccade errors (failures to inhibit prepotent responses) on the antisaccade task regardless of task condition (gap/overlap). Prosaccade error rates were associated with the level of higher-order (e.g. compulsions, preoccupations) but not sensorimotor repetitive behaviors in ASD.
CONCLUSIONS
Neurocognitive disturbances in voluntary behavioral control suggest that alterations in frontostriatal systems contribute to higher-order repetitive behaviors in ASD.
摘要
背景
自闭症谱系障碍（ASD）患者存在执行认知控制方面的缺陷，包括抑制优势反应的能力下降。这些缺陷可能是该疾病相关重复行为模式的基础。
方法
18名自闭症谱系障碍患者和15名年龄及智商匹配的健康个体进行了一项反扫视任务和一项视觉引导扫视控制任务，每个任务都有间隙和重叠条件。使用修订版自闭症诊断访谈量表（ADI-R）获得重复行为的测量数据，并与神经认知任务表现相关联进行检查。
结果
无论任务条件（间隙/重叠）如何，自闭症谱系障碍患者在反扫视任务中的顺向扫视错误率（未能抑制优势反应）均有所增加。顺向扫视错误率与自闭症谱系障碍中高阶（如强迫行为、先占观念）而非感觉运动重复行为的水平相关。
结论
自愿行为控制中的神经认知障碍表明，额纹状体系统的改变导致了自闭症谱系障碍中的高阶重复行为。
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2
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Brain. 2008 Apr;131(Pt 4):971-86. doi: 10.1093/brain/awm307. Epub 2007 Dec 24.
3
Predictors of perceived negative impact in mothers of children with autism spectrum disorder.自闭症谱系障碍患儿母亲感知到的负面影响的预测因素。
Am J Ment Retard. 2007 Nov;112(6):450-61. doi: 10.1352/0895-8017(2007)112[450:POPNII]2.0.CO;2.
4
The relationship between executive functioning, central coherence, and repetitive behaviors in the high-functioning autism spectrum.高功能自闭症谱系中执行功能、中心连贯性与重复行为之间的关系。
Autism. 2007 Sep;11(5):437-51. doi: 10.1177/1362361307079606.
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6
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7
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9
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10
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Neuropsychopharmacology. 2007 Jan;32(1):197-205. doi: 10.1038/sj.npp.1301199. Epub 2006 Oct 4.
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