Deckelbaum R J, Tall A R, Small D M
J Lipid Res. 1977 Mar;18(2):164-8.
The properties of human plasma very low density lipoproteins (VLDL), low density lipoproteins (LDL), and their extracted lipids were compared using calorimetric, X-ray scattering, and polarizing microscopy techniques. Intact LDL, and cholesterol esters isolated from LDL and VLDL each undergo reversible changes in their physical state around body temperature. These transitions are associated with ordered liquid crystalline to liquid phase changes of the cholesterol esters. In contrast to LDL, VLDL has no reversible transitions and shows no evidence of ordered liquid crystalline structures between 10 and 45 degrees C. Therefore, unlike LDL, VLDL does not contain a separate cholesterol ester region capable of undergoing cooperative melting. Solubility studies at 37 degrees C of cholesterol esters and triglyceride isolated from VLDL show that even at a weight ratio of 1:1, which greatly exceeds the relative amount of cholesterol esters in VLDL, cholesterol ester is completely soluble in triglyceride. Thus, the cholesterol ester in VLDL is not sequestered in a separate domain within VLDL, but is dissolved in the liquid core of the particle.
利用量热法、X射线散射法和偏光显微镜技术，对人血浆极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）及其提取的脂质的性质进行了比较。完整的LDL以及从LDL和VLDL中分离出的胆固醇酯在体温附近其物理状态都会发生可逆变化。这些转变与胆固醇酯从有序液晶相向液相的变化有关。与LDL不同，VLDL没有可逆转变，并且在10至45摄氏度之间没有显示出有序液晶结构的证据。因此，与LDL不同，VLDL不包含能够进行协同熔化的单独胆固醇酯区域。对从VLDL中分离出的胆固醇酯和甘油三酯在37摄氏度下进行的溶解度研究表明，即使在重量比为1:1（大大超过VLDL中胆固醇酯的相对含量）时，胆固醇酯也能完全溶解于甘油三酯中。因此，VLDL中的胆固醇酯不是被隔离在VLDL内的一个单独区域中，而是溶解在颗粒的液体核心中。
