Bhattacharya Sudhindra M
S.C.Das Memorial Medical and Research Center, Kolkata, India.
Int J Gynaecol Obstet. 2009 Apr;105(1):29-31. doi: 10.1016/j.ijgo.2008.11.031. Epub 2009 Jan 19.
To compare the prevalence of abnormal glucose tolerance (AGT) among women with polycystic ovary syndrome (PCOS) and controls, and assess risk factors associated with PCOS.
A fasting oral glucose tolerance test after ingestion of 75 g of glucose was administered to 264 women with and 116 without PCOS. Moreover, fasting glucose, insulin, and testosterone levels were measured in the women with PCOS. Body mass index (BMI), waist-to-hip ratio (WHR), and homeostasis model assessment-insulin resistance (HOMA-IR) were calculated for each woman with PCOS.
The AGT prevalence was 14.4% in the PCOS group and 11.2% in the control group (P=0.17). The women with both PCOS and AGT had significantly higher BMIs, WHRs, testosterone levels, and HOMA-IR values than those with normal glucose tolerance.
While AGT was not associated with PCOS, the women with both PCOS and AGT were significantly more obese, hyperandrogenic, and insulin resistant than those with PCOS and normal glucose tolerance.
比较多囊卵巢综合征（PCOS）女性与对照组中糖耐量异常（AGT）的患病率，并评估与PCOS相关的危险因素。
对264例患有PCOS的女性和116例未患PCOS的女性进行口服75 g葡萄糖后的空腹口服葡萄糖耐量试验。此外，还测量了患有PCOS的女性的空腹血糖、胰岛素和睾酮水平。计算了每位患有PCOS的女性的体重指数（BMI）、腰臀比（WHR）和稳态模型评估胰岛素抵抗（HOMA-IR）。
PCOS组AGT患病率为14.4%，对照组为11.2%（P=0.17）。患有PCOS和AGT的女性的BMI、WHR、睾酮水平和HOMA-IR值显著高于糖耐量正常的女性。
虽然AGT与PCOS无关，但患有PCOS和AGT的女性比患有PCOS且糖耐量正常的女性明显更肥胖、雄激素水平更高且胰岛素抵抗更强。
