Yang Hai-Yan, Ma Yan, Lu Xin-Hong, Liang Xing-Huan, Suo Ying-Jun, Huang Zhen-Xing, Lu De-Cheng, Qin Ying-Fen, Luo Zuo-Jie
Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 6, Shuangyong Road, Nanning, 530021 Guangxi, China.
Department of Ultrasonic Diagnosis, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Ann Endocrinol (Paris). 2015 Oct;76(5):620-7. doi: 10.1016/j.ando.2015.08.002. Epub 2015 Oct 26.
Aberrant circulating adipokines are considered to be related to the pathological mechanism of polycystic ovary syndrome (PCOS). This study aims to evaluate the relationship between plasma omentin-1 levels, metabolic and hormonal parameters in the setting of non-obese Chinese women with PCOS.
This was a case-controlled, cross-sectional study of 153 non-obese (BMI<25kg/m(2)) PCOS and 114 age-matched healthy non-obese control individuals. Levels of plasma omentin-1, fasting blood glucose, insulin and sexual hormones and ovary volume were analyzed in all subjects.
Plasma omentin-1 levels of non-obese PCOS individuals were significantly lower than in healthy non-obese controls. Body Mass Index (BMI), homeostasis model of assessment for insulin resistance index (HOMA-IR), levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), LH/FSH ratio and ovary volume (OV) were significantly higher in subjects with PCOS than controls. In the HOMA-IR stratified subgroups, PCOS individuals with insulin resistance had lower omentin-1 than those without insulin resistance after BMI adjustment. Omentin-1 was negatively correlated with BMI, HOMA-IR and fasting insulin. Multiple linear regressions revealed that BMI contributed to omentin-1 levels. Ovary volume was negatively correlated to HOMA-IR but had no correlation with omentin-1.
Plasma omentin-1 concentrations were decreased in the non-obese PCOS group. Insulin resistance could further decrease plasma omentin-1 in non-obese individuals with PCOS independent of BMI status.
异常循环的脂肪因子被认为与多囊卵巢综合征（PCOS）的病理机制有关。本研究旨在评估非肥胖中国PCOS女性中血浆网膜素-1水平、代谢及激素参数之间的关系。
这是一项病例对照横断面研究，纳入153名非肥胖（BMI<25kg/m²）PCOS患者和114名年龄匹配的健康非肥胖对照个体。分析了所有受试者的血浆网膜素-1、空腹血糖、胰岛素、性激素水平及卵巢体积。
非肥胖PCOS患者的血浆网膜素-1水平显著低于健康非肥胖对照。PCOS患者的体重指数（BMI）、胰岛素抵抗稳态模型评估指数（HOMA-IR）、睾酮、黄体生成素（LH）、卵泡刺激素（FSH）水平、LH/FSH比值及卵巢体积（OV）均显著高于对照组。在HOMA-IR分层亚组中，调整BMI后，有胰岛素抵抗的PCOS患者的网膜素-1水平低于无胰岛素抵抗者。网膜素-1与BMI、HOMA-IR及空腹胰岛素呈负相关。多元线性回归显示BMI对网膜素-1水平有影响。卵巢体积与HOMA-IR呈负相关，但与网膜素-1无关。
非肥胖PCOS组血浆网膜素-1浓度降低。胰岛素抵抗可使非肥胖PCOS个体的血浆网膜素-1进一步降低，且独立于BMI状态。
