[结核病相关免疫重建炎症综合征]

[Tuberculosis-associated immune reconstitution inflammatory syndrome].

作者信息

Leone S, Nicastri E, Giglio S, Corpolongo A, Narciso P, Acone N

机构信息

U.O.C. Malattie Infettive, AORN San Giuseppe Moscati, Avellino, Italy.

出版信息

Infez Med. 2008 Dec;16(4):193-9.

PMID:19155683

Abstract

The prognosis of HIV-infected patients has dramatically improved since the advent of HAART. The immune recovery associated with HAART may result in immuno-pathological reactions and clinical deterioration when HAART is initiated in patients with tuberculosis (TB). This phenomenon is defined as immune reconstitution inflammatory syndrome (IRIS). In this review, we summarise the epidemiology, clinical presentations and management of TB-associated IRIS.

摘要

自高效抗逆转录病毒治疗（HAART）出现以来，HIV感染患者的预后有了显著改善。当对合并结核病（TB）的患者启动HAART时，与HAART相关的免疫恢复可能会导致免疫病理反应和临床病情恶化。这种现象被定义为免疫重建炎症综合征（IRIS）。在本综述中，我们总结了与结核病相关的IRIS的流行病学、临床表现及管理。