Unal Mehmet, Korkut Ali Kubilay, Kosem Mesut, Ertunc Vedat, Ozcan Mustafa, Caglar Nizamettin
Department of Cardiovascular Surgery, Dogan Hospital, 34290 Istanbul, Turkey.
Tex Heart Inst J. 2008;35(4):402-5.
Spontaneous coronary artery dissection, which causes acute coronary syndrome and can result in sudden death, is rare; but its true incidence is underestimated, since most patients die suddenly, without diagnosis. The aim of this study was to show the importance of prompt diagnosis and treatment. In reviewing the records of 5,000 consecutive patients who underwent coronary angiography between January 2001 and August 2006, we found 6 cases of spontaneous coronary artery dissection (an incidence rate of 0.12%). Five patients presented with left main coronary artery dissection and 1 patient, with right coronary artery dissection. Angioplasty with stenting failed in the patient with right coronary artery dissection. Coronary artery bypass surgery was performed in all patients. The patient with right coronary artery dissection died of sepsis on the 30th postoperative day. The other 5 patients (83.3%) are still free of symptoms, and they had negative results on stress tests at the 6- and 12-month follow-up visits after coronary artery bypass surgery. The clinical presentation of spontaneous left main coronary artery dissection was similar to that of atherosclerotic disease. However, early diagnosis of spontaneous coronary artery dissection by means of coronary angiography is of paramount importance, because urgent coronary artery bypass grafting can be lifesaving.
自发性冠状动脉夹层可导致急性冠状动脉综合征并可能引发猝死,这种情况较为罕见;但其实际发病率被低估了,因为大多数患者突然死亡,未得到诊断。本研究的目的是表明及时诊断和治疗的重要性。在回顾2001年1月至2006年8月期间连续5000例接受冠状动脉造影的患者记录时,我们发现了6例自发性冠状动脉夹层(发病率为0.12%)。5例患者表现为左主干冠状动脉夹层,1例患者为右冠状动脉夹层。右冠状动脉夹层患者的血管成形术加支架置入失败。所有患者均接受了冠状动脉搭桥手术。右冠状动脉夹层患者术后第30天死于败血症。其他5例患者(83.3%)仍无症状,在冠状动脉搭桥手术后6个月和12个月的随访中,他们的负荷试验结果均为阴性。自发性左主干冠状动脉夹层的临床表现与动脉粥样硬化疾病相似。然而,通过冠状动脉造影早期诊断自发性冠状动脉夹层至关重要,因为紧急冠状动脉搭桥术可挽救生命。