Sellerio A L, Bassetti B, Isambert H, Cosentino Lagomarsino M
Università degli Studi di Milano, Dip. Fisica. Via Celoria 16, 20133, Milano, Italy.
Mol Biosyst. 2009 Feb;5(2):170-9. doi: 10.1039/b815339f. Epub 2008 Nov 25.
We present a comparative analysis of large-scale topological and evolutionary properties of transcription networks in three species: the two distant bacteria E. coli and B. subtilis, and the yeast S. cerevisiae. The study focuses on the global aspects of feedback and hierarchy in transcriptional regulatory pathways. While confirming that gene duplication has a significant impact on the shaping of all the analyzed transcription networks, our results point to distinct trends between the bacteria, which display a hierarchical network structure with short transcription cascades, and yeast, which seems able to sustain a higher wiring complexity, including larger feedback, longer transcription cascades, and the combinatorial use of heterodimers made of duplicate transcription factors, absent in E. coli.
两种亲缘关系较远的细菌——大肠杆菌和枯草芽孢杆菌，以及酵母——酿酒酵母。该研究聚焦于转录调控途径中反馈和层级结构的全局特征。在确认基因复制对所有分析的转录网络形成有重大影响的同时，我们的结果表明，细菌呈现出具有短转录级联的层级网络结构，而酵母似乎能够维持更高的连接复杂性，包括更大的反馈、更长的转录级联以及由重复转录因子组成的异二聚体的组合使用，大肠杆菌中则不存在这种情况，二者之间存在明显差异。
