Reiners C
Clinic for Nuclear Medicine, University of Essen.
Exp Clin Endocrinol. 1991 May;97(2-3):275-85. doi: 10.1055/s-0029-1211078.
I-131 treatment of Basedow's disease is effective and safe. Relatively high energy doses to the thyroid in the range of 150-200 Gray are needed in endemic goiter areas, where immunogenic hyperthyroidism may coincide with functional autonomy. Induction of euthyroidism by low doses of antithyroid drugs (methimazole, carbimazole) before I-131 treatment prevents complications and has no significant influence on outcome of I-131 therapy. As compared to alternative therapeutic modalities, the risks of I-131 are low.
碘-131治疗毒性弥漫性甲状腺肿有效且安全。在地方性甲状腺肿地区，由于免疫性甲状腺功能亢进可能与功能性自主性并存，因此需要给予甲状腺相对高能量剂量，范围在150 - 200格雷。在碘-131治疗前，用低剂量抗甲状腺药物（甲巯咪唑、卡比马唑）诱导甲状腺功能正常可预防并发症，且对碘-131治疗的结果无显著影响。与其他治疗方式相比，碘-131的风险较低。
