• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

[通过一次性测定乙醇麻醉持续时间的结果来选择短睡眠和长睡眠小鼠的不可靠性]

[The unreliability of selecting short- and long-sleep mice by the results of a one-time determination of the duration of ethanol anesthesia].

作者信息

Lapin I P, Mutovkina L G

出版信息

Farmakol Toksikol. 1991 May-Jun;54(3):64-5.

PMID:1915829
Abstract

Duration of ethanol (5 g/kg, orally) anesthesia was measured in male C57 B1/6 and white SHR (bred from Swiss) mice in three consecutive experiments with a 7-day interval between them. The number of short-sleep (SS) mice (duration of anesthesia was 30 min) and long-sleep (LS) mice (duration of anesthesia was over 120 min) in the selected groups decreased in the second and third experiments. This means that groups of SS and LS taken one and two weeks after the first selection for any experiment are not homogeneous because only in some animals the initial characteristics remain.

摘要

在雄性C57 B1/6和白色SHR(源自瑞士)小鼠中,连续进行了三次实验,每次实验间隔7天,测量经口给予乙醇(5 g/kg)后的麻醉持续时间。在第二次和第三次实验中,所选组中短睡眠(SS)小鼠(麻醉持续时间为30分钟)和长睡眠(LS)小鼠(麻醉持续时间超过120分钟)的数量减少。这意味着在任何实验的首次选择后1周和2周选取的SS和LS组并不同质,因为只有部分动物仍保留初始特征。

相似文献

1
[The unreliability of selecting short- and long-sleep mice by the results of a one-time determination of the duration of ethanol anesthesia].[通过一次性测定乙醇麻醉持续时间的结果来选择短睡眠和长睡眠小鼠的不可靠性]
Farmakol Toksikol. 1991 May-Jun;54(3):64-5.
2
[The contrary effects of ethanol on the behavior of short- and long-sleep C57BL/6 mice in a dark-light chamber].[乙醇对短睡眠和长睡眠C57BL/6小鼠在明暗箱中行为的相反影响]
Eksp Klin Farmakol. 1996 Mar-Apr;59(2):50-2.
3
Phenotypic and genotypic relationships between ethanol tolerance and sensitivity in mice selectively bred for initial sensitivity to ethanol (SS and LS) or development of acute tolerance (HAFT and LAFT).在对乙醇初始敏感性(SS和LS)或急性耐受性发展(HAFT和LAFT)进行选择性培育的小鼠中,乙醇耐受性与敏感性之间的表型和基因型关系。
Alcohol Clin Exp Res. 2000 May;24(5):595-604.
4
A comparison of the effects of chronic nicotine infusion on tolerance to nicotine and cross-tolerance to ethanol in long- and short-sleep mice.长期和短期睡眠小鼠中慢性尼古丁输注对尼古丁耐受性和乙醇交叉耐受性影响的比较。
J Pharmacol Exp Ther. 1993 Sep;266(3):1390-7.
5
Thyroid status during postnatal maturation of the brain in mice genetically bred for differences in ethanol sensitivity.在因乙醇敏感性差异而进行基因培育的小鼠大脑产后成熟过程中的甲状腺状态。
J Pharmacol Exp Ther. 1986 Jun;237(3):874-80.
6
Relationship of brain ethanol metabolism to the hypnotic effect of ethanol. II: Studies in selectively bred rats and mice.脑乙醇代谢与乙醇催眠作用的关系。II:对选择性育种大鼠和小鼠的研究。
Alcohol Clin Exp Res. 2001 Jul;25(7):982-8.
7
Ethanol-induced changes in tyrosine hydroxylase activity in adrenal glands of mice selectively bred for differences in sensitivity to ethanol.
J Pharmacol Exp Ther. 1985 Feb;232(2):315-21.
8
Role of brain tyrosine availability in mediating differences in ethanol sensitivity in long-sleep and short-sleep mice.脑内酪氨酸可用性在介导长睡眠和短睡眠小鼠乙醇敏感性差异中的作用。
J Pharmacol Exp Ther. 1989 Aug;250(2):556-64.
9
MK-801-induced locomotor activity in long-sleep x short-sleep recombinant inbred mouse strains: correlational analysis with low-dose ethanol and provisional quantitative trait loci.MK-801诱导的长睡眠×短睡眠重组近交小鼠品系的自发活动:与低剂量乙醇的相关性分析及初步数量性状基因座
Alcohol Clin Exp Res. 1999 Nov;23(11):1721-9.
10
Effect of exogenous GM1 on ethanol sensitivity in selectively bred mouse lines.
Alcohol Clin Exp Res. 1997 Jun;21(4):661-5.