Lapin I P, Mirzaev S
Eksp Klin Farmakol. 1996 Mar-Apr;59(2):50-2.
Marked differences in the behavior of short (SS) and long-sleep (LS) male C57BL/6 mice were found 21 h after a one-time oral administration of ethanol (0.5, 1.0, and 2.0 g/kg), namely a significant prolongation of the time spent in the light compartment, i.e., the inhibition of dark preference (of the hole reflex) was observed only in SS mice. 15 min after ethanol administration opposite changes took place the time spent in the light compartment was shortened in SS mice and prolonged in LS mice. A smaller dose of ethanol (0.5 g/kg) activated the locomotion in SS mice and inhibited it in LS mice. It seems promising to compare the behavior of SS and LS mice over a period of the ethanol withdrawal.
一次性口服给予乙醇（0.5、1.0和2.0克/千克）21小时后，发现雄性C57BL/6短睡眠（SS）小鼠和长睡眠（LS）小鼠的行为存在显著差异，即仅在SS小鼠中观察到其在亮区停留时间显著延长，也就是暗偏好（洞反射）受到抑制。给予乙醇15分钟后，出现了相反的变化，SS小鼠在亮区的停留时间缩短，而LS小鼠则延长。较小剂量的乙醇（0.5克/千克）能激活SS小鼠的运动，却抑制LS小鼠的运动。比较SS小鼠和LS小鼠在乙醇戒断期间的行为似乎很有前景。
