Komano H, Homma K, Natori S
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
FEBS Lett. 1991 Sep 9;289(2):167-70. doi: 10.1016/0014-5793(91)81061-c.
Addition of antibodies against sapecin to the culture medium of NIH-Sape-4 cells derived from a Sarcophaga embryo greatly inhibited cell proliferation, whereas addition of sapecin stimulated cell proliferation. These results suggest that sapecin is involved in the proliferation of embryonic cells of Sarcophaga. Sapecin is known to have potent antibacterial activity, so it seems to have two different biological functions: i.e. protection against bacterial infection and stimulation of embryonic cell proliferation.
向源自麻蝇胚胎的NIH-Sape-4细胞的培养基中添加抗杀菌肽的抗体，极大地抑制了细胞增殖，而添加杀菌肽则刺激了细胞增殖。这些结果表明，杀菌肽参与了麻蝇胚胎细胞的增殖。已知杀菌肽具有强大的抗菌活性，因此它似乎具有两种不同的生物学功能：即预防细菌感染和刺激胚胎细胞增殖。
