Sullivan Stephen R, Scott Jeffrey R, Cole Jana K, Chi Ying, Anaya Daniel A, Byrd David R, Yeung Raymond S, Mann Gary N, Isik Frank F
Department of Surgery, University of Washington, Seattle, USA.
Ann Plast Surg. 2009 Feb;62(2):144-8. doi: 10.1097/SAP.0b013e31817dadc8.
Head and neck melanoma often approaches critical structures. Therefore, excision is often limited, leading to positive margins, and increased local recurrence. Immediate reconstruction carries concern for rearrangement or concealment of cancerous tissues. Therefore, reconstruction is often delayed until confirming negative margins on permanent pathology. Our purpose is to identify variables associated with a positive margin and establish criteria for reconstruction timing. We reviewed 117 consecutive patients who underwent wide local excision of head and neck melanoma. Reconstruction was immediate for 107 and delayed for 10. Six percent of patients had a positive margin after wide local excision with no difference in incidence between immediate and delayed reconstruction (P = 0.11). Tumor characteristics associated with a positive margin were locally recurrent, ulcerated, and T4 tumors (P < 0.05); and delayed reconstruction should be considered in these circumstances. Immediate reconstruction is safe for the majority of head and neck melanoma and should be based on knowledge of tumor characteristics.
头颈部黑色素瘤常常侵犯关键结构。因此,切除范围往往受限,导致切缘阳性,并增加局部复发风险。即刻重建存在癌组织移位或隐匿的问题。所以,重建通常会延迟,直到永久病理检查确认切缘阴性。我们的目的是确定与切缘阳性相关的变量,并建立重建时机的标准。我们回顾了117例连续接受头颈部黑色素瘤广泛局部切除的患者。107例患者进行了即刻重建,10例患者进行了延迟重建。广泛局部切除后6%的患者切缘阳性,即刻重建和延迟重建的发生率无差异(P = 0.11)。与切缘阳性相关的肿瘤特征为局部复发、溃疡型和T4期肿瘤(P < 0.05);在这些情况下应考虑延迟重建。对于大多数头颈部黑色素瘤患者,即刻重建是安全的,应基于对肿瘤特征的了解来进行。