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足底黑色素瘤的即刻重建:一种范式转变。

Immediate Reconstruction for Plantar Melanoma: A Paradigm Shift.

作者信息

Oliver-Allen Hunter, Piper Merisa, Vaughn Carolyn, Sbitany Hani

机构信息

From the Division of Plastic Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA.

出版信息

Ann Plast Surg. 2017 May;78(5 Suppl 4):S194-S198. doi: 10.1097/SAP.0000000000001115.

DOI:10.1097/SAP.0000000000001115
PMID:28399024
Abstract

INTRODUCTION

Plantar melanoma tumors are traditionally treated with wide local excision based on depth of invasion, followed by delayed reconstruction once negative surgical margins are confirmed. However, delayed reconstruction requires care for an open wound, a prolonged treatment course, and the need for an additional surgery. Immediate reconstruction has been shown to be oncologically safe in head and neck melanoma, but little is described in the literature regarding immediate reconstruction in plantar melanoma. We present our experience with immediate reconstruction after wide local excision for lower extremity plantar melanomas.

METHODS

We performed a retrospective review of all patients with biopsy-proven plantar melanoma who underwent wide local excision followed by immediate reconstruction of any type between 1999 and 2014 at the University of California, San Francisco. Patient demographics, postoperative complications, reoperation rates, and oncologic outcomes were collected.

RESULTS

Thirty-eight patients were identified, with a mean follow-up of 34 months. Skin grafts were the most common method of reconstruction, followed by primary closure, local flaps, and free flaps. Only 1 patient had a major complication, which was skin graft loss requiring reoperation. Eight patients had either local or distant recurrence (21%).

DISCUSSION

Immediate reconstruction for plantar melanomas can be safely performed with recurrence rates comparable and in line with previously published studies of wide local excision for plantar melanoma. This technique has the potential to achieve oncologically safe outcomes with less overall morbidity.

摘要

引言

足底黑色素瘤传统上根据浸润深度进行广泛局部切除,一旦确认手术切缘阴性则进行延迟重建。然而,延迟重建需要护理开放性伤口、延长治疗过程且需要额外的手术。即刻重建已被证明在头颈部黑色素瘤中具有肿瘤学安全性,但关于足底黑色素瘤即刻重建的文献报道较少。我们介绍了对下肢足底黑色素瘤进行广泛局部切除后即刻重建的经验。

方法

我们对1999年至2014年在加利福尼亚大学旧金山分校接受活检证实的足底黑色素瘤且进行了广泛局部切除并随后进行任何类型即刻重建的所有患者进行了回顾性研究。收集了患者的人口统计学数据、术后并发症、再次手术率和肿瘤学结局。

结果

共确定了38例患者,平均随访34个月。植皮是最常见的重建方法,其次是一期缝合、局部皮瓣和游离皮瓣。只有1例患者出现了严重并发症,即植皮失败需要再次手术。8例患者出现局部或远处复发(21%)。

讨论

足底黑色素瘤的即刻重建可以安全进行,复发率与先前发表的足底黑色素瘤广泛局部切除研究相当且一致。该技术有可能在总体发病率较低的情况下实现肿瘤学安全的结果。

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1
Immediate Reconstruction for Plantar Melanoma: A Paradigm Shift.足底黑色素瘤的即刻重建:一种范式转变。
Ann Plast Surg. 2017 May;78(5 Suppl 4):S194-S198. doi: 10.1097/SAP.0000000000001115.
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The safety of and indications for immediate reconstruction of head and neck melanoma defects: our early experience.头颈部黑色素瘤缺损即刻重建的安全性及适应证:我们的早期经验
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World J Surg Oncol. 2016 Oct 19;14(1):269. doi: 10.1186/s12957-016-1019-x.
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Head and neck malignant melanoma: local recurrence rate following wide local excision and immediate reconstruction.头颈部恶性黑色素瘤:广泛局部切除并即刻重建后的局部复发率
Ann Plast Surg. 2012 Jan;68(1):33-6. doi: 10.1097/SAP.0b013e318212683a.
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Melanoma Extirpation with Immediate Reconstruction: The Oncologic Safety and Cost Savings of Single-Stage Treatment.黑色素瘤切除并即刻重建:单阶段治疗的肿瘤学安全性及成本节约
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引用本文的文献

1
Plantar melanoma is associated with certain poor prognostic histopathological factors, but not correlated with nodal involvement, recurrence, and worse survival.足底黑素瘤与某些预后不良的组织病理学因素相关,但与淋巴结受累、复发和更差的生存无关。
Clin Transl Oncol. 2018 May;20(5):607-612. doi: 10.1007/s12094-017-1755-6. Epub 2017 Sep 25.