Lammersfeld Carolyn A, King Jessica, Walker Sharon, Vashi Pankaj G, Grutsch James F, Lis Christopher G, Gupta Digant
Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL 60099, USA.
Nutr J. 2009 Jan 22;8:2. doi: 10.1186/1475-2891-8-2.
A number of components in soy appear to have anticancer properties, including the isoflavones, genistein and daidzein. The use of soy by women with breast cancer is now being questioned because of the estrogen-like effects of isoflavones and possible interactions with tamoxifen. Clinicians providing nutrition counseling to these women are concerned because the availability of soy foods has increased dramatically in the past few years. The goal of this study was to quantify the intake of isoflavones in women with breast cancer.
A cross-sectional study of 100 women with breast cancer treated at Cancer Treatment Centers of America(R) between 09/03 and 02/04. Each patient completed a soy food frequency questionnaire (FFQ) that was scored by Fred Hutchinson Cancer Research Center. Demographic and clinical predictors of soy intake were evaluated using one-way non-parametric Mann Whitney test and non-parametric spearman's rank correlation.
Mean age was 50.5 years (std. dev. = 9.4; range 31-70) and mean BMI was 27.3 kg/m2 (std. dev. = 6.75; range 17-59). Genistein and Daidzein consumption was limited to 65 patients with a mean intake of 11.6 mg/day (std. dev. = 21.9; range 0-97.4) and 7.6 mg/day (std. dev. = 14.1; range 0-68.9) respectively. Soy milk (37%) and pills containing soy, isoflavones, or "natural" estrogen (24%) were the two biggest contributors to isoflavone intake.
Our study suggests that the isoflavone intake of breast cancer patients at our hospital was quite variable. Thirty-five patients reported no soy intake. The mean daily intake of 11.6 mg genistein and 7.4 mg daidzein, is the equivalent of less than 1/4 cup of tofu per day. This amount is higher than what has been previously reported in non-Asian American women.
大豆中的许多成分似乎具有抗癌特性，包括异黄酮、染料木黄酮和大豆苷元。由于异黄酮的雌激素样作用以及可能与他莫昔芬发生相互作用，乳腺癌女性对大豆的食用如今受到质疑。过去几年大豆食品的可获得性显著增加，为这些女性提供营养咨询的临床医生对此感到担忧。本研究的目的是量化乳腺癌女性的异黄酮摄入量。
对2003年9月至2004年2月期间在美国癌症治疗中心接受治疗的100名乳腺癌女性进行横断面研究。每位患者完成一份大豆食品频率问卷（FFQ），该问卷由弗雷德·哈钦森癌症研究中心评分。使用单向非参数曼-惠特尼检验和非参数斯皮尔曼等级相关性评估大豆摄入量的人口统计学和临床预测因素。
平均年龄为50.5岁（标准差=9.4；范围31 - 70岁），平均体重指数为27.3kg/m²（标准差=6.75；范围17 - 59）。65名患者食用了染料木黄酮和大豆苷元，平均摄入量分别为11.6毫克/天（标准差=21.9；范围0 - 97.4）和7.6毫克/天（标准差=14.1；范围0 - 68.9）。豆浆（37%）和含有大豆、异黄酮或“天然”雌激素的药丸（24%）是异黄酮摄入的两大主要来源。
我们的研究表明，我院乳腺癌患者的异黄酮摄入量差异很大。35名患者报告未摄入大豆。染料木黄酮平均每日摄入量为11.6毫克，大豆苷元为7.4毫克，相当于每天食用不到1/4杯豆腐。这个量高于之前非亚裔美国女性的报告量。
