Ma Kai, Chang Dong, Gong Min, Ding Fang, Luo Aiping, Tian Feng, Liu Zhihua, Wang Tianyou
Department of Thoracic and Cardiovascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Cancer Invest. 2009 Mar;27(3):353-9. doi: 10.1080/07357900802254008.
Fra-1 is thought to play an important role in tumorigenesis and progression. This study aimed to investigate the expression and significance of Fra-1 in non-small-cell lung cancer (NSCLC). By analyzing with Western blot and immunohistochemistry, we found that Fra-1 is downregulated in NSCLC, compared with normal bronchial epithelium. Further, the low expression of Fra-1 correlates with advanced tumor stage and poor survival. Meanwhile, the distinct cytoplasmic location of Fra-1 was found in almost all immunoreactive cells. These findings reveal a potential nontranscriptional function of Fra-1, and indicate that Fra-1 might play a role in the progression and prognosis of NSCLC.
Fra-1被认为在肿瘤发生和发展中起重要作用。本研究旨在探讨Fra-1在非小细胞肺癌（NSCLC）中的表达及其意义。通过蛋白质印迹法和免疫组织化学分析，我们发现与正常支气管上皮相比，Fra-1在NSCLC中表达下调。此外，Fra-1的低表达与肿瘤晚期和较差的生存率相关。同时，在几乎所有免疫反应性细胞中都发现了Fra-1独特的细胞质定位。这些发现揭示了Fra-1潜在的非转录功能，并表明Fra-1可能在NSCLC的进展和预后中发挥作用。
