Sun J D, Dahl A R, Gillett N A, Barr E B, Crews M L, Eidson A F, Bechtold W E, Burt D G, Dieter M P, Hobbs C H
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute.
Fundam Appl Toxicol. 1991 Jul;17(1):150-8. doi: 10.1016/0272-0590(91)90247-2.
Ferrocene (dicyclopentadienyl iron; CAS No. 102-54-5) is a relatively volatile, organometallic compound used as a chemical intermediate, a catalyst, and as an antiknock additive in gasoline. It is of particular interest because of its structural similarities to other metallocenes that have been shown to be carcinogenic. F344/N rats and B6C3F1 mice were exposed to 0, 2.5, 5.0, 10, 20, and 40 mg ferrocene vapor/m3, 6 hr/day for 2 weeks. During these exposures, there were no mortality and no observable clinical signs of ferrocene-related toxicity in any of the animals. At the end of the exposures, male rats exposed to the highest level of ferrocene had decreased body-weight gains relative to the weight gained by filtered air-exposed control rats, while body-weight gains for all groups of both ferrocene- and filtered air-exposed female rats were similar. Male mice exposed to the highest level of ferrocene also had decreased body-weight gains, relative to controls, while female mice had relative decreases in body-weight gains at the three highest exposure levels. Male rats had a slight decrease in relative liver weight at the highest level of exposure, whereas no relative differences in organ weights were seen in female rats. Male mice had exposure-relative decreases in liver and spleen weights, and an increase in thymus weights, relative to controls. For female mice, relative decreases in organ weights were seen for brain, liver, and spleen. No exposure-related gross lesions were seen in any of the rats or mice at necropsy. Histopathological examination was done only on the nasal turbinates, lungs, liver, and spleen.(ABSTRACT TRUNCATED AT 250 WORDS)
二茂铁（二环戊二烯基铁；化学物质登记号：102 - 54 - 5）是一种相对易挥发的有机金属化合物，用作化学中间体、催化剂以及汽油中的抗爆添加剂。因其结构与其他已被证明具有致癌性的金属茂相似，故而备受关注。将F344/N大鼠和B6C3F1小鼠暴露于浓度分别为0、2.5、5.0、10、20和40毫克二茂铁蒸汽/立方米的环境中，每天暴露6小时，持续2周。在这些暴露期间，所有动物均未出现死亡情况，也未观察到与二茂铁相关的毒性临床症状。暴露结束时，暴露于最高浓度二茂铁的雄性大鼠体重增加量相较于暴露于过滤空气的对照大鼠有所下降，而暴露于二茂铁和过滤空气的所有雌性大鼠组的体重增加量相似。暴露于最高浓度二茂铁的雄性小鼠体重增加量相较于对照组也有所下降，而雌性小鼠在三个最高暴露水平下体重增加量相对下降。暴露于最高浓度的雄性大鼠肝脏相对重量略有下降，而雌性大鼠的器官重量未见相对差异。雄性小鼠肝脏和脾脏重量相对于对照组有与暴露相关的下降，胸腺重量增加。对于雌性小鼠，大脑、肝脏和脾脏的器官重量出现相对下降。尸检时，在任何大鼠或小鼠中均未发现与暴露相关的大体病变。仅对鼻甲、肺、肝脏和脾脏进行了组织病理学检查。（摘要截断于250字）
