大鼠鼻黏膜上皮细胞膜中细胞色素P-450依赖的单加氧酶活性
Cytochrome P-450 dependent monooxygenase activity in rat nasal epithelial membranes.
作者信息
Hadley W M, Dahl A R
出版信息
Toxicol Lett. 1982 Mar;10(4):417-22. doi: 10.1016/0378-4274(82)90240-5.
PMID:7089996
Abstract
Cytochrome P-450 was found in nasal epithelial membranes (NEM) of the rat. The quantity was 12% that of liver on a per mg of microsomal protein basis and 1.6 times that of lung on the same basis. Metabolism of p-nitroanisole was faster by microsomes from NEM than by microsomes from liver or lungs while the metabolism rate of aniline by microsomes from NEM was between that of microsomes from liver and lung.
摘要
在大鼠的鼻上皮膜（NEM）中发现了细胞色素P-450。以每毫克微粒体蛋白计算，其含量为肝脏的12%，在相同基础上是肺的1.6倍。与来自肝脏或肺的微粒体相比，来自NEM的微粒体对对硝基苯甲醚的代谢更快，而来自NEM的微粒体对苯胺的代谢速率介于来自肝脏和肺的微粒体之间。
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