Nazarov type cyclization on an osmium-dienylcarbene complex.

The Nazarov reaction is an acid-catalyzed 4pi-electrocyclic ring closure of dienylketones, which affords cyclopentenones. This type of cyclization has been increasing in interest over the years, due to the importance of the construction of five-membered rings in the synthesis of natural products. However, one potential problem is that the carbonyl group necessary for the cyclization to occur may not be required in the final synthetic target and can sometimes be difficult to remove or modify. One possible solution is to design analogous reactions which do not suffer the carbonyl dependence.