Polo-like kinase 1 在肿瘤发生中的平衡。
The balance of Polo-like kinase 1 in tumorigenesis.
机构信息
Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 1520, Ann Arbor, Michigan, 48109, USA.
出版信息
Cell Div. 2009 Jan 22;4:4. doi: 10.1186/1747-1028-4-4.
Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role to ensure the normal mitosis. Interestingly, overexpression of Plk1 is associated with tumor development and could serve as a prognostic marker for many cancers. Due to Plk1 overexpression, several Plk1 inhibitors have been developed and tested for the cancer treatment. However, in a recent study, it has been suggested that down-regulation of Plk1 could also induce aneuploidy and tumor formation in vivo. Therefore, a normal level of Plk1 is important for mitosis. And caution should be taken when Plk1 inhibitors are used in the clinical trial and their side effects including tumorigenesis should be carefully evaluated.
丝氨酸/苏氨酸激酶家族中的 Polo 样激酶 1（Plk1）具有 Polo 盒结构域，在细胞周期进程中具有相似但不重叠的功能。Plk1 对保证正常的有丝分裂起着关键作用。有趣的是，Plk1 的过表达与肿瘤的发生发展有关，并可作为许多癌症的预后标志物。由于 Plk1 的过表达，已经开发出几种 Plk1 抑制剂并用于癌症治疗。然而，最近的一项研究表明，Plk1 的下调也会在体内诱导非整倍体和肿瘤形成。因此，Plk1 的正常水平对有丝分裂很重要。在临床试验中使用 Plk1 抑制剂时应谨慎，并应仔细评估其包括致癌性在内的副作用。
Zotero 插件