Unit for Psychiatric Research, Aalborg Psychiatric Hospital, 9100 Aalborg, Denmark.
J Psychopharmacol. 2010 Jul;24(7):965-71. doi: 10.1177/0269881108100320. Epub 2009 Jan 22.
Clozapine is, in most countries, underutilized and the initiation of clozapine is often delayed. The purpose of this study is to investigate the reasons for the delay and the underutilization of clozapine. One hundred psychiatrists were interviewed by phone. The interview was a structured interview with questions regarding attitude to, knowledge of and experiences with clozapine. Forty-eight (48%) psychiatrists had treatment responsibility of fewer than five patients treated with clozapine and 31 of the interviewed psychiatrists (31%) had started clozapine within the last 3 months. Seven psychiatrists (7%) had never prescribed clozapine despite the fact that they had been working more than five years in general psychiatry. Sixty-four psychiatrists (64%) would rather combine two antipsychotics than use clozapine. Sixty-six psychiatrists (66%) believed that patients treated with clozapine were less satisfied with their treatment when compared with those treated with other atypical antipsychotics. Many psychiatrists are reluctant to use clozapine and this might be due to less experience and knowledge of clozapine. A reason for the low awareness of clozapine's properties might be that clozapine is now a generic drug, and therefore, the marketing and education in using the drug is sparse.
氯氮平在大多数国家未得到充分利用，且氯氮平的起始治疗常被延迟。本研究旨在调查氯氮平使用不足和起始治疗延迟的原因。通过电话采访了 100 名精神科医生。访谈采用结构化访谈，问题涉及对氯氮平的态度、知识和经验。48 名（48%）精神科医生负责治疗的氯氮平治疗患者少于 5 例，其中 31 名（31%）接受采访的精神科医生在过去 3 个月内开始使用氯氮平。尽管他们从事一般精神病学工作超过 5 年，但仍有 7 名（7%）精神科医生从未开过氯氮平。64 名（64%）精神科医生宁愿合用两种抗精神病药，也不愿使用氯氮平。66 名（66%）精神科医生认为，与使用其他非典型抗精神病药治疗的患者相比，使用氯氮平治疗的患者对治疗的满意度较低。许多精神科医生不愿意使用氯氮平，这可能是由于他们对氯氮平的经验和知识较少。对氯氮平特性认识不足的一个原因可能是氯氮平现在是一种仿制药，因此，对该药的营销和教育相对较少。
