[Formulation optimization of controlled porosity osmotic-pump tablets of total paeony glycosides].

OBJECTIVE

To prepare controlled porosity osmotic-pump tablets of total paeony glycosides (TPG) and establish the relationship between formulation factors of membrane and drug release rate.

METHOD

Uniform design was used to achieve the quantitative relationship between the release rate and formulation factors of membrane. Optimized prescription was calculated from the regression equation.

RESULT

A significant correlation and a fine precision of the regession equation were obtained. Controlled porosity osmotic-pump tablets of TPG were prepared based on the calculations, and the drug release profile was in accord with zero-order kinetics (r = 0.9902).

CONCLUSION

Uniform design is a convenient and efficient approach for formulation optimization of controlled porosity osmotic-pump tablets.