School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Drug Dev Ind Pharm. 2009 Dec;35(12):1430-8. doi: 10.3109/03639040902988566.
The purpose of this study was to design a 24-hour controlled porosity osmotic pump system that utilizes polyvinyl pyrrolidone (PVP) as an osmotic-suspending/release retarding agent of drugs.
Osmotic tablet cores containing various ratios of ketoprofen and PVP were prepared by wet granulation and initially spray coated with similar solution of cellulose acetate. A formulation containing ketoprofen and PVP at a ratio of 1:7 was selected for further studies.
The final formulation containing PVP K-30 in the tablet core augmented the release of ketoprofen (poorly water-soluble) up to 90 % over 24 hours much higher than either PVP K-25 or PVP K-90 and retarded the release of pseudoephedrine HCl (highly water-soluble) up to 18 hours.
This study proposed the dual use of PVP in osmotic pump systems containing solids to modulate the release of either poorly or highly water-soluble drug.
本研究旨在设计一种 24 小时控释渗透泵系统，该系统利用聚乙烯吡咯烷酮（PVP）作为药物的渗透悬浮/释放延缓剂。
通过湿法制粒和初始喷涂醋酸纤维素的相似溶液，制备含有不同比例酮洛芬和 PVP 的渗透片芯。选择含有酮洛芬和 PVP 比例为 1:7 的配方进行进一步研究。
片剂核心中含有 PVP K-30 的最终配方使酮洛芬（水溶性差）的释放增加到 24 小时内的 90%以上，远高于 PVP K-25 或 PVP K-90，并延缓了盐酸伪麻黄碱（水溶性高）的释放长达 18 小时。
本研究提出了在含有固体的渗透泵系统中双重使用 PVP 来调节水溶性差或水溶性好的药物的释放。
