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[动脉内检查:怀疑为胆固醇结晶栓塞病]

[Endo arterial investigation: suspicious for the cholesterol crystal embolism disease].

作者信息

Fehri W, Lahidheb D, Bouladi W, Rahal N, Smiri Z, Barakett N, Hajlaoui N, Salah O, Mhenni H, Haouala H

机构信息

Service de Cardiologie, Hôpital Militaire Principal d'lnstruction de Tunis.

出版信息

Tunis Med. 2007 Nov;85(11):975-8.

PMID:19166153
Abstract

BACKGROUND

Cholesterol crystal embolism (CCE) is a rare disorder which can complicate cardiac catheterization, angiographic studies and cardiovascular surgery. The CCE exposes to a great risk of renal failure and it can even threaten life by means of a multi visceral failing syndrome.

AIM

Report a new case of CCE following cardiac catheterization.

CASE

We report the observation of a 63-year-old patient who had a coronary angiography via the right femoral artery after a myocardial infarction. This examination has showed a multi-vessel coronary disease. 15 days later, the patient presented purplish and painful discoloration of his toes. The laboratory findings showed a mild inflammatory syndrome and eosinophilia at 700 / microL. There was not a renal dysfunction nor proteinuria nor hematuria. We performed a skin biopsy and made the diagnosis of CCE. Trans oesophageal echography objectified an irregular atherosclerotic plaque in the isthmic aorta. The CT scan revealed a spindle-shaped aneurysm in the end of the abdominal aorta. This aneurysm contains a marginal surrounding thrombosis with high embolic risk. The patient was put under clopidogrel, enoxaparin, simvastatin, colchicine and atenolol and operated successfully.

CONCLUSION

The two particularities of this observation are, on one hand, the absence of a renal involvement, which represents the main prognostic factor of the CCE. On the other hand, the CCE has revealed a very unstable aneurysm of the aorta which could be complicated during the cardiac catheterisation. The CCE is a difficult diagnosis that must be remembered before any cardiac catheterisation, because it often reflects unstable aortic atherosclerotic lesions.

摘要

背景

胆固醇结晶栓塞(CCE)是一种罕见的疾病,可使心脏导管插入术、血管造影研究和心血管手术出现并发症。CCE有发生肾衰竭的巨大风险,甚至可通过多脏器功能衰竭综合征威胁生命。

目的

报告1例心脏导管插入术后发生CCE的新病例。

病例

我们报告1例63岁患者,在心肌梗死后经右股动脉进行冠状动脉造影。该检查显示有多支冠状动脉病变。15天后,患者出现脚趾青紫、疼痛性变色。实验室检查结果显示有轻度炎症综合征,嗜酸性粒细胞增多至700/微升。无肾功能不全、蛋白尿或血尿。我们进行了皮肤活检,诊断为CCE。经食管超声心动图检查发现峡部主动脉有不规则动脉粥样硬化斑块。CT扫描显示腹主动脉末端有一梭形动脉瘤。该动脉瘤有边缘性周围血栓形成,具有很高的栓塞风险。患者接受氯吡格雷、依诺肝素、辛伐他汀、秋水仙碱和阿替洛尔治疗,并成功进行了手术。

结论

该病例的两个特殊之处在于,一方面,无肾脏受累,而肾脏受累是CCE的主要预后因素。另一方面,CCE显示出主动脉有一个非常不稳定的动脉瘤,在心脏导管插入术期间可能会出现并发症。CCE是一种难以诊断的疾病,在任何心脏导管插入术前都必须牢记,因为它常反映主动脉不稳定的动脉粥样硬化病变。

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[Endo arterial investigation: suspicious for the cholesterol crystal embolism disease].[动脉内检查:怀疑为胆固醇结晶栓塞病]
Tunis Med. 2007 Nov;85(11):975-8.
2
[Lethal cholesterol crystal embolization syndrome after operation for abdominal aortic aneurysm].腹主动脉瘤手术后的致死性胆固醇结晶栓塞综合征
Kyobu Geka. 2011 Mar;64(3):195-9.
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Cholesterol crystal embolization (CCE) after cardiac catheterization: a case report and a review of 36 cases in the Japanese literature.心脏导管插入术后胆固醇结晶栓塞(CCE):一例病例报告及对日本文献中36例病例的综述
Jpn Heart J. 2003 Sep;44(5):767-74. doi: 10.1536/jhj.44.767.
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