Shao Jing, Wang Hongbing, Yang Li, Deng Xiaoyan
College of Bioengineering, Chongqing University, Chongqing 400044, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Dec;25(6):1462-5.
The researches on Rho family proteins have been progressing very fast recently. Rho proteins mainly regulate the reorganization of actin cytoskeleton, thus controlling the cell morphologic changes and the motility. There is a close relationship between Rho proteins and tumors; under the function of regulators and effectors, the activation of Rho proteins can enhance cell motility, induce gene expression in cell cycle progression, and promote the degradation and re-establishment of extracellular matrix. Accordingly, Rho proteins play a crucial role in regulating tumor cells' proliferation, apoptosis, invasion, metastasis and other biological behaviors. Further researches on Rho proteins can help to clarify the mechanism involved in these effects, thus providing a potential evidence in anti-tumor therapy.
近年来，对Rho家族蛋白的研究进展非常迅速。Rho蛋白主要调节肌动蛋白细胞骨架的重组，从而控制细胞形态变化和运动性。Rho蛋白与肿瘤之间存在密切关系；在调节因子和效应器的作用下，Rho蛋白的激活可增强细胞运动性，诱导细胞周期进程中的基因表达，并促进细胞外基质的降解和重建。因此，Rho蛋白在调节肿瘤细胞的增殖、凋亡、侵袭、转移及其他生物学行为中起着关键作用。对Rho蛋白的进一步研究有助于阐明这些作用所涉及的机制，从而为抗肿瘤治疗提供潜在依据。
