Price L S, Collard J G
Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Semin Cancer Biol. 2001 Apr;11(2):167-73. doi: 10.1006/scbi.2000.0367.
Rho-like GTPases regulate both cell-cell and cell-matrix adhesions and can influence the motile and invasive properties of tumour cells in vitro. Increased Rac signalling can promote either cell-cell adhesion or motility depending on the cell type and composition of the extracellular matrix. Ultimately, the balance of Rac and Rho activities and intracellular localization appears to be critical in determining the cellular phenotype.
类Rho GTP酶调节细胞间和细胞与基质的黏附，并能在体外影响肿瘤细胞的运动和侵袭特性。Rac信号增强可促进细胞间黏附或运动，这取决于细胞类型和细胞外基质的组成。最终，Rac和Rho活性的平衡以及细胞内定位在决定细胞表型方面似乎至关重要。
