Nishiyabu Ryuhei, Hashimoto Nozomi, Cho Ten, Watanabe Kazuto, Yasunaga Takefumi, Endo Ayataka, Kaneko Kenji, Niidome Takuro, Murata Masaharu, Adachi Chihaya, Katayama Yoshiki, Hashizume Makoto, Kimizuka Nobuo
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka Nishi-ku, Fukuoka 819-0395, Japan.
J Am Chem Soc. 2009 Feb 18;131(6):2151-8. doi: 10.1021/ja8058843.
Amorphous nanoparticles of supramolecular coordination polymer networks are spontaneously self-assembled from nucleotides and lanthanide ions in water. They show intrinsic functions such as energy transfer from nucleobase to lanthanide ions and excellent performance as contrast enhancing agents for magnetic resonance imaging (MRI). Furthermore, adaptive inclusion properties are observed in the self-assembly process: functional materials such as fluorescent dyes, metal nanoparticles, and proteins are facilely encapsulated. Dyes in these nanoparticles fluoresce in high quantum yields with a single exponential decay, indicating that guest molecules are monomerically wrapped in the network. Gold nanoparticles and ferritin were also wrapped by the supramolecular shells. In addition, these nucleotide/lanthanide nanoparticles also serve as scaffolds for immobilizing enzymes. The adaptive nature of present supramolecular nanoparticles provides a versatile platform that can be utilized in a variety of applications ranging from material to biomedical sciences. As examples, biocompatibility and liver-directing characteristics in in vivo tissue localization experiments are demonstrated.
超分子配位聚合物网络的无定形纳米颗粒在水中由核苷酸和镧系离子自发自组装而成。它们具有诸如从核碱基到镧系离子的能量转移等内在功能，并且作为磁共振成像（MRI）的造影剂具有优异性能。此外，在自组装过程中观察到适应性包合特性：荧光染料、金属纳米颗粒和蛋白质等功能材料很容易被包裹。这些纳米颗粒中的染料以高量子产率发出荧光，具有单指数衰减，表明客体分子以单体形式包裹在网络中。金纳米颗粒和铁蛋白也被超分子壳层包裹。此外，这些核苷酸/镧系纳米颗粒还可作为固定酶的支架。当前超分子纳米颗粒的适应性本质提供了一个通用平台，可用于从材料科学到生物医学科学的各种应用。例如，在体内组织定位实验中证明了生物相容性和肝脏导向特性。
