Bottrill Melanie, Kwok Lilian, Long Nicholas J
Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK.
Chem Soc Rev. 2006 Jun;35(6):557-71. doi: 10.1039/b516376p. Epub 2006 May 2.
Magnetic Resonance Imaging is perhaps the most important and prominent technique in diagnostic clinical medicine and biomedical research. Its success and development as an imaging technique has been aided by the characteristics of contrast agents that enhance signal intensities and improve specificity. Gadolinium(iii) remains the dominant starting material for contrast agent design but other lanthanide ions (and other oxidation states i.e. +2) are also being increasingly investigated as alternatives to gadolinium(III) within laboratory conditions. This critical review provides a concise summary of the MRI-active gadolinium(III) complexes to date--their pros and cons, an outline of contrast agents based on other lanthanide ions (e.g. europium, dysprosium), and directs the reader to newer, more speculative areas of lanthanide-containing contrast agent design.
磁共振成像或许是诊断临床医学和生物医学研究中最重要、最突出的技术。作为一种成像技术，其成功与发展得益于能够增强信号强度并提高特异性的造影剂的特性。钆（III）仍然是造影剂设计的主要起始原料，但在实验室条件下，其他镧系离子（以及其他氧化态，即 +2）作为钆（III）的替代物也正受到越来越多的研究。这篇批判性综述简要总结了迄今为止具有磁共振成像活性的钆（III）配合物——它们的优缺点，概述了基于其他镧系离子（如铕、镝）的造影剂，并引导读者关注含镧系造影剂设计中更新颖、更具推测性的领域。
