Brömme H J, Zimmermann T, Blech W
Institut für Biochemie, Martin-Luther Universität Halle-Wittenberg, Germany.
Horm Metab Res. 1991 Jun;23(6):262-5. doi: 10.1055/s-2007-1003669.
Pancreatic secretion and hepatic removal of insulin have been measured in thioacetamide (TAA)-induced compensated rat liver cirrhosis in perfusion experiments. Peripheral plasma concentrations of glucose and insulin were slightly decreased in TAA-treated rats. Pancreatic secretion and hepatic removal of insulin remained unchanged by the TAA-treatment. Thus, even in morphologically and biochemically proven experimental liver cirrhosis, insulin secretion and removal may not be disturbed.
在灌注实验中，已对硫代乙酰胺（TAA）诱导的代偿性大鼠肝硬化模型的胰岛素胰腺分泌及肝脏清除情况进行了测定。TAA处理的大鼠外周血浆葡萄糖和胰岛素浓度略有降低。TAA处理对胰岛素的胰腺分泌及肝脏清除没有影响。因此，即使在形态学和生物化学证实的实验性肝硬化中，胰岛素的分泌和清除也可能未受干扰。
