Kobalava Zh D, Villeval'de S V, Isikova Kh V
Kardiologiia. 2009;49(1):51-8.
Arterial hypertension, insulin resistance, diabetes mellitus are associated with obesity. However exact mechanisms of this association have not been determined yet. Biologically active substances produced by adipose tissue participate in pathogenesis of cardiovascular diseases and complications. In this review we present data on the role of adiponectin -- adipocytokine with unique antiatherogenic, antiinflammatory, and insulin sensitizing properties. Hypoadiponectinemia is considered to be potentially modifiable cardiovascular risk factor and novel therapeutic target. Therapy with PPAR gamma agonists, blockers of renin-angiotensin and sympathetic nervous systems is associated with elevation of concentration of adiponectin.
动脉高血压、胰岛素抵抗、糖尿病都与肥胖相关。然而，这种关联的确切机制尚未确定。脂肪组织产生的生物活性物质参与心血管疾病及其并发症的发病机制。在这篇综述中，我们介绍了脂联素（一种具有独特抗动脉粥样硬化、抗炎和胰岛素增敏特性的脂肪细胞因子）作用的数据。低脂联素血症被认为是一种潜在可改变的心血管危险因素和新的治疗靶点。使用过氧化物酶体增殖物激活受体γ激动剂、肾素 - 血管紧张素阻滞剂和交感神经系统阻滞剂进行治疗与脂联素浓度升高有关。
