Sun Yiyi, Xun Keli, Wang Changguang, Zhao Haiyu, Bi Huichang, Chen Xiuping, Wang Yitao
School of Pharmacy, Chengdu Medical College, Chengdu, China.
Cardiovasc Ther. 2009 Spring;27(1):59-75. doi: 10.1111/j.1755-5922.2008.00069.x.
A large number of studies revealed that adiponectin, a protein secreted specifically by adipose tissue, exhibits antiinflammatory, antiatherogenic, and antidiabetic properties. This 247-amino acid protein contains four differentiable domains and exists in five different configurations, which binds three kinds of receptors. The plasma adiponectin concentration is at amazing microgram level and the gender difference is very clear. Obese subjects showed decreased plasma level of adiponectin while exercise seems to restore it. Many researchers demonstrated that it could be a reliable biomarker for multiple diseases. However, there is controversy about its role in inflammation since its plasma concentration decreases in some inflammatory diseases and increases under some other inflammatory conditions. The signal transduction pathway is still not very clear yet. Could adiponectin be a promising drug target?
大量研究表明，脂联素是一种由脂肪组织特异性分泌的蛋白质，具有抗炎、抗动脉粥样硬化和抗糖尿病特性。这种含247个氨基酸的蛋白质包含四个可区分的结构域，并以五种不同的构象存在，可与三种受体结合。血浆脂联素浓度处于惊人的微克水平，且性别差异非常明显。肥胖受试者的血浆脂联素水平降低，而运动似乎可使其恢复。许多研究人员证明，它可能是多种疾病的可靠生物标志物。然而，关于其在炎症中的作用存在争议，因为在某些炎症性疾病中其血浆浓度会降低，而在其他一些炎症条件下会升高。其信号转导途径仍不太清楚。脂联素会成为一个有前景的药物靶点吗？
