Saggese G, Cesaretti G, Cinquanta L, Giannessi N, Bracaloni C, Di Spigno G, Cioni C
Department of Pediatrics, University of Pisa, Italy.
Horm Res. 1991;35(1):25-9. doi: 10.1159/000181871.
Spontaneous growth hormone (GH) secretion in 116 short children was studied by sampling blood for GH measurement every 20 min over 24 h. We calculated 24-h mean GH concentration (MGHC), diurnal 12-h MGHC (dMGHC) and nocturnal 12-h MGHC (nMGHC). The children were subdivided into four groups: prepubertal children with 'classical' GH deficiency (group 1, n = 12, low responses to two provocative stimuli tests and MGHC less than 3 ng/ml), prepubertal children with 'nonclassical' GH deficiency (group 2, n = 36, normal GH responses to two provocative tests and MGHC less than 3 ng/ml), short normal children (normal GH responses to two provocative tests and MGHC greater than 3 ng/ml) at stage P1 of puberty (group 3, n = 41) and at stage P2 of puberty (group 4, n = 27). The values of MGHC, dMGHC and nMGHC were significantly higher in groups 3 and 4 than in groups 1 and 2, and in group 4 than in group 3. The values of MGHC and nMGHC were significantly higher in group 2 than in group 1. MGHC correlated highly with nMGHC and dMGHC (r = 0.97 and 0.94, respectively; p less than 0.001). On the basis of regression equations between MGHC and nMGHC or dMGHC, the study of the diagnostic accuracy showed values higher for nMGHC than for dMGHC: 94.1 vs. 89.6% for sensitivity, and 93.7 vs. 89.7% for specificity, respectively.
通过在24小时内每隔20分钟采集血液样本测定生长激素（GH），对116名身材矮小儿童的自发性GH分泌情况进行了研究。我们计算了24小时平均GH浓度（MGHC）、日间12小时MGHC（dMGHC）和夜间12小时MGHC（nMGHC）。这些儿童被分为四组：青春期前患有“经典型”GH缺乏症的儿童（第1组，n = 12，对两种激发刺激试验反应低下且MGHC低于3 ng/ml），青春期前患有“非经典型”GH缺乏症的儿童（第2组，n = 36，对两种激发试验的GH反应正常且MGHC低于3 ng/ml），青春期P1阶段的身材矮小正常儿童（对两种激发试验的GH反应正常且MGHC高于3 ng/ml）（第3组，n = 41）以及青春期P2阶段的身材矮小正常儿童（第4组，n = 27）。第3组和第4组的MGHC、dMGHC和nMGHC值显著高于第1组和第2组，且第4组高于第3组。第2组的MGHC和nMGHC值显著高于第1组。MGHC与nMGHC和dMGHC高度相关（r分别为0.97和0.94；p < 0.001）。基于MGHC与nMGHC或dMGHC之间的回归方程，诊断准确性研究显示nMGHC的值高于dMGHC：敏感性分别为94.1%对89.6%，特异性分别为93.7%对89.7%。
