Sanz M T, Rochiccioli P
Horm Res. 1985;22(1-2):17-23. doi: 10.1159/000180067.
The authors compared diurnal growth hormone (GH) secretion with GH secretion during sleep in 24 children with delayed growth. In group I (children with normal response to provocative tests), the level of daytime secretion was lower than that of nocturnal secretion. In 3 of 9 cases, daytime secretion was abnormal, whereas nocturnal secretion was normal. In 2 cases, both diurnal and nocturnal secretion were abnormal, but response to provocative stimuli was normal. In group II (children with a false partial GH deficiency, i.e. with inadequate response to provocative tests, GH peak less than 11 ng/ml and normal nocturnal secretion), the results were comparable with those of group I, with extremely low diurnal secretion in 6 of 9 cases. In group III (children presenting true partial GH deficiency, i.e. GH less than 11 ng/ml in response to provocative tests together with abnormal nocturnal secretion), both diurnal and nocturnal GH secretion were insufficient, with nonexistent diurnal secretion in 5 of 6 cases. Diurnal secretion does not seem to be a reliable indicator of 24-hour spontaneous secretion.
作者比较了24名生长发育迟缓儿童的日间生长激素（GH）分泌情况与睡眠期间的GH分泌情况。在第一组（对激发试验反应正常的儿童）中，日间分泌水平低于夜间分泌水平。9例中有3例日间分泌异常，而夜间分泌正常。2例日间和夜间分泌均异常，但对激发刺激的反应正常。在第二组（假性部分生长激素缺乏的儿童，即对激发试验反应不足、GH峰值低于11 ng/ml且夜间分泌正常）中，结果与第一组相当，9例中有6例日间分泌极低。在第三组（呈现真性部分生长激素缺乏的儿童，即对激发试验反应时GH低于11 ng/ml且夜间分泌异常）中，日间和夜间GH分泌均不足，6例中有5例日间分泌不存在。日间分泌似乎不是24小时自发分泌的可靠指标。
