Quincey C, Raitt N, Bell J, Ellis I O
Department of Histopathology, City Hospital, Nottingham, UK.
Histopathology. 1991 Jul;19(1):83-7. doi: 10.1111/j.1365-2559.1991.tb00898.x.
The monoclonal antibody NCRC-11, which has epithelial membrane antigen (EMA)-like immunoreactivity, was used to identify intracytoplasmic lumina in a series of 105 adenocarcinomas from various sites and in 283 breast carcinomas; 55% of the non-breast carcinomas and all breast carcinomas except one of spindle cell type contained intracytoplasmic lumina. The highest frequency (16.4% of tumour cells) was found in invasive lobular carcinoma of the breast. The use of antibodies with EMA reactivity is advocated in the routine investigation of metastatic and undifferentiated tumours.
具有上皮膜抗原（EMA）样免疫反应性的单克隆抗体NCRC-11，被用于鉴定一系列来自不同部位的105例腺癌和283例乳腺癌中的胞质内腔；55%的非乳腺癌以及除1例梭形细胞型外的所有乳腺癌都含有胞质内腔。在乳腺浸润性小叶癌中发现频率最高（占肿瘤细胞的16.4%）。在转移性和未分化肿瘤的常规检查中，提倡使用具有EMA反应性的抗体。
