Navarro Albert, Ancizu Iciar
Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain.
Prev Med. 2009 Mar;48(3):298-302. doi: 10.1016/j.ypmed.2008.12.019. Epub 2009 Jan 6.
Falls are a common problem facing elderly people and are associated with considerable mortality and morbidity. The objective of this paper is to study the application of the conditional model as an alternative for the statistical analysis of the occurrence of falls and their associated factors.
Cohort study. We select all ninety-eight residents admitted during the year 2007 in a long-term care centre, Seville, Spain. Five models were fitted: Negative binomial, standard Cox for the first fall, standard Cox for all falls, Andersen-Gill model, and Prentice-Williams-Peterson model.
The crude incidence rate of falls was 26.3 per 100 person-months. The median time to fall decreases depending on the falls previously experienced, while the hazard rises. The AG's standard errors are between 1.4 and 2.7 times bigger than those estimated by Standard Cox. The major differences between marginal models were in the "Barthel 25-60" coefficient, where the conditional model attributed an HR=2.39 versus HR=3.77 estimated by the extension model.
As the risk increases depending on the falls previously suffered by an individual, the PWP-conditional model becomes an interesting alternative for obtaining unbiased and precise estimations of coefficients associated with possible risk factors of falls.
跌倒是老年人面临的常见问题,与相当高的死亡率和发病率相关。本文的目的是研究条件模型作为跌倒发生及其相关因素统计分析的替代方法的应用。
队列研究。我们选取了2007年在西班牙塞维利亚一家长期护理中心收治的所有98名居民。拟合了五个模型:负二项式模型、首次跌倒的标准Cox模型、所有跌倒的标准Cox模型、Andersen-Gill模型和Prentice-Williams-Peterson模型。
跌倒的粗发病率为每100人月26.3次。跌倒的中位时间根据之前经历的跌倒次数而减少,而风险增加。Andersen-Gill模型的标准误差比标准Cox模型估计的标准误差大1.4至2.7倍。边际模型之间的主要差异在于“巴氏指数25 - 60”系数,其中条件模型得出的风险比(HR)为2.39,而扩展模型估计的风险比为3.77。
由于风险因个体之前遭受的跌倒次数而增加,Prentice-Williams-Peterson条件模型成为获得与跌倒可能风险因素相关系数的无偏且精确估计的一种有趣替代方法。