Ishiyama Aki, Otoguro Kazuhiko, Namatame Miyuki, Nishihara Aki, Furusawa Toshiaki, Masuma Rokuro, Shiomi Kazuro, Takahashi Yoko, Ichimura Michio, Yamada Haruki, Omura Satoshi
Research Center for Tropical Diseases, Center for Basic Research, Kitasato University, Tokyo, Japan.
J Antibiot (Tokyo). 2008 Oct;61(10):627-32. doi: 10.1038/ja.2008.83.
Our on-going screening program to discover new antitrypanosomal antibiotics has been evaluating compounds isolated from soil microorganisms as well as investigating the antibiotic libraries of the Kitasato Institute for Life Sciences and BioFrontier Laboratories of Kyowa Hakko Kogyo Co., Ltd. We have now discovered two compounds, KS-505a and alazopeptin, which exhibit moderate antitrypanosomal characteristics. We report here the in vitro and in vivo antitrypanosomal activities and cytotoxicities of KS-505a and alazopeptin, compared with some commonly-used antitrypanosomal drugs. This is the first report of in vitro and in vivo antitrypanosomal activities of either KS-505a or alazopeptin.
我们正在进行的用于发现新型抗锥虫抗生素的筛选项目，一直在评估从土壤微生物中分离出的化合物，同时也在研究北里生命科学研究所以及协和发酵工业株式会社生物前沿实验室的抗生素文库。我们现已发现两种化合物，KS - 505a和丙唑肽，它们具有中等抗锥虫特性。在此，我们报告KS - 505a和丙唑肽的体外和体内抗锥虫活性及细胞毒性，并与一些常用的抗锥虫药物进行比较。这是关于KS - 505a或丙唑肽体外和体内抗锥虫活性的首次报道。
