绿灰霉素B，一种来自青霉菌FR11的新型抗耐甲氧西林金黄色葡萄球菌（MRSA）药物。
Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11.
作者信息
Zheng Chang-Ji, Yu Hyung-Eun, Kim Eun-Hee, Kim Won-Gon
机构信息
Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
出版信息
J Antibiot (Tokyo). 2008 Oct;61(10):633-7. doi: 10.1038/ja.2008.84.
A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structure of viridicatumtoxin B was determined on the basis of MS and NMR data. Viridicatumtoxin B inhibited the growth of Staphylococcus aureus including methicillin-resistant S. aureus and quinolone-resistant S. aureus with MIC (microg/ml) of 0.5, which is similar with that of vancomycin, but 8-64 times higher activity than that of tetracycline.
从青霉属菌株FR11液体发酵培养物的菌丝体中分离出一种名为绿黄霉素B的新型四环素类抗生素以及已知化合物绿黄霉素。基于质谱和核磁共振数据确定了绿黄霉素B的结构。绿黄霉素B抑制金黄色葡萄球菌的生长，包括耐甲氧西林金黄色葡萄球菌和耐喹诺酮金黄色葡萄球菌，其最低抑菌浓度（μg/ml）为0.5，与万古霉素相似，但活性比四环素高8至64倍。
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