Sohn Mi-Jin, Zheng Chang-Ji, Kim Won-Gon
Functional Metabolites Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
J Antibiot (Tokyo). 2008 Nov;61(11):687-91. doi: 10.1038/ja.2008.98.
In the course of screening for FabG inhibitors from microbial sources, a new 24-membered ring lactone named macrolactin S, along with the known compound macrolactin B, has been isolated from the mycelium of liquid fermentation cultures of Bacillus sp. AT28. The structure of macrolactin S was determined on the basis of MS and NMR data. Macrolactin S showed a dose-dependent inhibition of Staphylococcus aureus FabG, not inhibiting S. aureus FabI. Also macrolactin S inhibited the growth of S. aureus, Bacillus subtilis, and Escherichia coli.
在从微生物来源筛选法布G抑制剂的过程中，一种名为大环内酯素S的新型24元环内酯，与已知化合物大环内酯素B一起，从芽孢杆菌属AT28液体发酵培养物的菌丝体中分离出来。大环内酯素S的结构是根据质谱和核磁共振数据确定的。大环内酯素S对金黄色葡萄球菌法布G表现出剂量依赖性抑制作用，而不抑制金黄色葡萄球菌法布I。此外，大环内酯素S还抑制金黄色葡萄球菌、枯草芽孢杆菌和大肠杆菌的生长。
