Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, GR-Athens 15771.
Chem Biodivers. 2010 Jan;7(1):186-95. doi: 10.1002/cbdv.200800309.
Four new tetracyclic brominated diterpenes, 1-4, were isolated from the organic extract of Sphaerococcus coronopifolius, collected from the rocky coasts of Corfu Island. The structures of the new natural products, as well as their relative configurations, were elucidated on the basis of extensive spectral analyses, including 2D-NMR experiments. The isolated metabolites were evaluated for their antibacterial activity against a panel of bacteria including multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) with MIC values in the range of 16-128 microg/ml.
从科孚岛岩石海岸采集的球果卷柏有机提取物中分离得到四个新的四环溴代二萜 1-4。基于广泛的光谱分析，包括 2D-NMR 实验，阐明了新天然产物的结构及其相对构型。对分离得到的代谢产物进行了抗菌活性评价，以包括多重耐药（MDR）和耐甲氧西林金黄色葡萄球菌（MRSA）在内的一系列细菌为研究对象，MIC 值范围为 16-128μg/ml。
