Holt D W, Fashola T O, Johnston A
Analytical Unit, St. George's Hospital Medical School, London, U.K.
Immunol Lett. 1991 Jul;29(1-2):99-103. doi: 10.1016/0165-2478(91)90208-r.
This paper reviews the current data which provide a rationale for the measurement of cyclosporin as a guide to therapy. Methodological problems related to sample matrix and analytical technique are considered, and the most commonly used methods considered. Factors which could influence the clinical interpretation of cyclosporin measurements are examined, including other drug therapy, compliance with therapy, cyclosporin metabolites, pharmacokinetic variables and sample timing. It is concluded that, whilst isolated measurements do not offer a definitive diagnostic tool, taken in context they can be of considerable value in optimising therapy.
本文回顾了当前的数据，这些数据为环孢素的测量提供了治疗指导依据。考虑了与样本基质和分析技术相关的方法学问题，并对最常用的方法进行了探讨。研究了可能影响环孢素测量临床解释的因素，包括其他药物治疗、治疗依从性、环孢素代谢物、药代动力学变量和采样时间。得出的结论是，虽然单次测量并不能提供一个确定的诊断工具，但结合具体情况来看，它们在优化治疗方面可能具有相当大的价值。
