Holt D W, Johnston A
Analytical Unit, St George's Hospital Medical School, London, UK.
J Autoimmun. 1992 Apr;5 Suppl A:177-82. doi: 10.1016/0896-8411(92)90032-l.
This paper describes some of the methodological problems related to the measurement of cyclosporin. The clinical value of the measurements following organ transplantation are discussed and those areas also applying to autoimmune indications are highlighted. It is concluded that the routine use of cyclosporin monitoring in samples from patients receiving the drug for autoimmune indications is unlikely to be of significant value as a guide to efficacy or toxicity. However, some settings, such as suspected poor patient compliance, for the avoidance of potential drug interactions and for research on the absorption of new formulations are considered to be useful applications of the methodology.
本文描述了与环孢素测量相关的一些方法学问题。讨论了器官移植后测量的临床价值，并强调了那些也适用于自身免疫性适应症的领域。得出的结论是，对于接受环孢素治疗自身免疫性适应症的患者样本进行常规监测，作为疗效或毒性的指导不太可能具有显著价值。然而，某些情况，如怀疑患者依从性差、避免潜在药物相互作用以及研究新制剂的吸收情况，被认为是该方法的有用应用。
