Fatima Atiya, Gupta Vivek K, Luqman Suaib, Negi Arvind S, Kumar J K, Shanker Karuna, Saikia Dharmendra, Srivastava Suchita, Darokar M P, Khanuja Suman P S
Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (CSIR), Kukrail Picnic Spot Road, P. O. CIMAP, Lucknow 226015, India.
Phytother Res. 2009 Aug;23(8):1190-3. doi: 10.1002/ptr.2726.
Glabridin, an active constituent of Glycyrrhiza glabra roots, was found to be active against both yeast and filamentous fungi. Glabridin also showed resistance modifying activity against drug resistant mutants of Candida albicans at a minimum inhibitory concentration of 31.25-250 microg/mL. Although the compound was reported earlier to be active against Candida albicans, but this is the first report of its activity against drug resistant mutants.
光甘草定是光果甘草根的一种活性成分，已发现其对酵母和丝状真菌均具有活性。光甘草定在最低抑菌浓度为31.25 - 250微克/毫升时，对白色念珠菌的耐药突变体也表现出耐药修饰活性。尽管该化合物早些时候有报道称对白色念珠菌有活性，但这是其对耐药突变体活性的首次报道。
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